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GBP1 drives STAT3 activation and PD-L1 upregulation through CDK9.

Journal: Neoplasia (New York, N.Y.)

Article Title: GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape

doi: 10.1016/j.neo.2025.101232

Figure Lengend Snippet: GBP1 drives STAT3 activation and PD-L1 upregulation through CDK9.

Article Snippet: The STAT3 inhibitor STAT3-IN-13 (HY-150603) and the CDK9 inhibitor LDC000067 (Synonyms: LDC067, HY-15878) were purchased from MedChemExpress (Monmouth Junction, USA). siRNAs were procured from RiboBio (Guangzhou, China).

Techniques: Activation Assay